When it comes to hair loss treatment, Minoxidil and Finasteride are usually the first names mentioned. Both are approved by the US FDA and known to effectively combat hair loss — but both can cause side effects in some individuals. Now a new player called Pyrilutamide has emerged as a potential alternative.
In this article based on his educational video, Dr. John Watts — dermatologist, trichologist and hair transplant surgeon in Hyderabad — gives an overview of this promising drug, which is still under clinical trials.
What is Pyrilutamide?
Pyrilutamide was developed by the Chinese pharmaceutical company Kintor Pharmaceutical. It is currently undergoing various stages of clinical trials and is awaiting approval from the US FDA before it can be introduced to the market.
Dr. Watts stresses that the trials are still ongoing, and more research and data are expected on its efficacy and potential long-term side effects. "It's crucial to gather substantial medical literature and evidence before the drug can be considered a safe and reliable option," said Dr. John Watts.
How does it compare with Finasteride?
One notable difference is the impact on sexual function. Finasteride has been associated with sexual problems in certain users, whereas Pyrilutamide — according to the trials conducted so far — has not shown any adverse effects on sexual function.
The mechanism is also different. Pyrilutamide acts directly on the Androgen Receptor, instead of targeting DHT, which is how Finasteride works to prevent hair loss. In addition, clinical trials have observed potential for Pyrilutamide in treating cancer and acne.
How does it compare with Minoxidil?
Minoxidil is known to have side effects such as dryness of hair, increased heart palpitations due to its vasodilator effect, and the formation of white flaky substances in some patients. Pyrilutamide, on the other hand, does not exhibit such effects.
Like Minoxidil, Pyrilutamide can be used as a topical lotion. It is available in dosage forms ranging from 0.5 mg, 1 mg, 2 mg and 4 mg up to 12 mg, and can be applied to the scalp with a gentle massage, similar to other hair lotions.
What are the downsides?
Pyrilutamide is not without disadvantages. Clinical trials have revealed it can lead to contact dermatitis and reddish features on the scalp. Fortunately, these conditions tend to resolve on their own once the medication is discontinued.
The bigger limitation is availability. The drug has not been approved by the US FDA, and its efficacy still needs to be assessed in different demographic populations — including Indian patients.
The bottom line
Pyrilutamide shows promising results as an alternative to Minoxidil and Finasteride, particularly because it has not shown sexual side effects or Minoxidil-type effects in trials so far. But it is not yet on the market, and its long-term safety is unproven. As Dr. Watts puts it: "More trials are required to establish Pyrilutamide as a viable option for hair loss treatment. It requires US FDA approval before it can enter markets. We have to wait and watch." Until then, stick to proven, prescribed treatments.
This article is for educational purposes only and is not a substitute for professional medical advice. Consult a qualified dermatologist for diagnosis and treatment.
Frequently asked questions
What is Pyrilutamide?
Pyrilutamide is an experimental topical hair loss drug developed by Kintor Pharmaceutical. It acts directly on the Androgen Receptor and is undergoing clinical trials, awaiting US FDA approval.
How is Pyrilutamide different from Finasteride?
Finasteride targets DHT and has been associated with sexual problems in some users. Pyrilutamide acts on the Androgen Receptor and, in trials so far, has not shown adverse effects on sexual function.
Does Pyrilutamide have side effects?
Trials revealed it can cause contact dermatitis and reddish features on the scalp, but these tend to resolve on their own once the medication is discontinued.
Can I buy Pyrilutamide now?
No. It is still under clinical trials and has not received US FDA approval, so it is not yet available on the market.
