Whether or not Minoxidil topical lotion will work puts many users in a dilemma. Traditionally, you need about 6 months of regular usage before you can find out if the drug is actually working for you — a long and uncertain wait.
In this article based on his educational video, Dr. John Watts — dermatologist, trichologist and hair transplant surgeon in Hyderabad — explains a time-saving alternative: the Minoxidil Response DNA Test kit developed by Trichogene, how to use it step by step, and what can be done if you fail the test.
What the test actually measures
The test kit analyzes the activity of an enzyme called SULT1A1, known as sulfotransferase. This matters because after you apply the topical lotion, Minoxidil undergoes a transformation into Minoxidil sulphate — and the test kit specifically detects the presence of SULT1A1 enzyme activity in your sample.
“A higher presence of enzyme activity suggests that Minoxidil will be effective for the patient. These people can continue to use their prescribed topical lotion without any dilemma. Conversely, if no enzyme activity is detected, it implies that Minoxidil may not work for that particular patient,” said Dr. John Watts.
In short, the test gives a positive or negative result — a quick, scientific insight that would otherwise take months of trial use to discover.
What if you fail the test?
A negative result is not the end of the road. Dr. Watts explains that the Tretinoin compound aids in enhancing the absorption of Minoxidil by stimulating the release of sulfotransferase enzymes — the same enzymes that improve Minoxidil effectiveness.
“These patients who fail the Minoxidil Response DNA Sample Test can follow a specific regimen that involves taking a dose of 0.1% Tretinoin compound for the first five days of each month. Following this initial treatment, they should continue with the regular dosage of Minoxidil as prescribed by their doctor,” informed Dr. John Watts.
How to use the test kit: step by step
1. Refrain from eating anything 30 minutes before sample collection.
2. Open the SalivaProtect kit by tearing the seal.
3. Take out the sample collection tube and swabs from the packet.
4. Rub the inner cheek for 30-45 seconds with the swab as instructed.
5. Open the sample collection tube and place the swab inside.
6. Close the tube and mix the contents by gently tapping.
7. Place the tube back into the sample kit and lock it tightly.
8. Ship the package at room temperature.
The bottom line
The Minoxidil Response DNA Test lets you scientifically determine whether you will respond to Minoxidil topical lotion — saving time, improving accuracy and helping plan treatment. And if the test says Minoxidil will not work for you, a Tretinoin-based regimen prescribed by your doctor may still improve your response. As always, use Minoxidil and any add-on treatment only under a dermatologist's guidance.
This article is for educational purposes only and is not a substitute for professional medical advice. Consult a qualified dermatologist for diagnosis and treatment.
Frequently asked questions
What is the Minoxidil Response DNA Test?
It is a saliva-based test kit developed by Trichogene that analyzes SULT1A1 (sulfotransferase) enzyme activity to predict whether Minoxidil topical lotion will work for you, without waiting around 6 months of trial use.
What does a positive or negative result mean?
Higher enzyme activity suggests Minoxidil will be effective and you can continue your prescribed lotion. If no enzyme activity is detected, Minoxidil may not work for you.
What can I do if I fail the Minoxidil Response Test?
Dr. John Watts explains that a regimen of 0.1% Tretinoin for the first five days of each month can stimulate sulfotransferase release and enhance Minoxidil absorption, followed by the regular Minoxidil dosage as prescribed by your doctor.
How is the sample collected?
You avoid eating for 30 minutes, rub the inner cheek with a swab for 30-45 seconds, seal the swab in the collection tube, and ship the kit at room temperature.
